Product Name

Methotrexate disodium salt

General description

Methotrexate Sodium is the sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties.

Synonym

disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate; Methotrexate disodium

Purity

≥98.0%(HPLC)

CAS Number

7413-34-5

Formula

C²⁰H²⁰N⁸Na²O⁵

Molecular Weight

498.4

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Pale yellow to yellow solid

Solubility(25℃)

DMSO

Slightly soluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Methotrexate Sodium is the sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties.

Application

1. Abortifacient Agents, Nonsteroidal

2. Antimetabolites, Antineoplastic

3. Antirheumatic Agents

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov