l General Information |
Product Name | Ouabain octahydrate |
General description | Ouabain octahydrate is a selective Na+/K+, -ATPase inhibitor. |
Synonym | 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside); Acocantherine; G-Strophanthin; 630-60-4 |
Purity | ≥95%(HPLC) | CAS Number | 11018-89-6 |
Formula | C29H44O12 · 8H2O | Molecular Weight | 728.77 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
l Biological Information |
Biochem/Physiol Actions | Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity. |
l Packaging & Storage |
Packaging | 5mg; 25mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
