l General Information |
Product Name | Rifabutin |
General description | Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. |
Synonym | Ansamycin; Ansatipine; Farmitalia; LM-427; Mycobutin |
Purity | ≥99%(HPLC) | CAS Number | 72559-06-9 |
Formula | C46H62N4O11 | Molecular Weight | 847.00 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Purple or light purple solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥35mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. |
Application | 1. Anti-Bacterial Agents 2. Antibiotics, Antitubercular |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
