l General Information |
Product Name | Leuprolide acetate |
General description | Leuprolide acetate is a potent synthetic long-acting agonist of gonadotropin-releasing hormone. |
Synonym | des-Gly10-[D-Leu6]-LH-RH ethylamide; Leuprorelin acetate |
Purity | ≥98%(HPLC) | CAS Number | 74381-53-6 |
Formula | C59H84N16O12 · xC2H4O2 | Molecular Weight | 1209.40(free base basis) |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥50mg/mL |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Used in the palliative treatment of advanced prostate cancer. Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis. Leuprolide Acetate is the acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. |
Application | 1. Antineoplastic Agents, Hormonal 2. Fertility Agents, Female |
l Packaging & Storage |
Packaging | 25mg; 100mg; 250mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
