l General Information |
Product Name | Prednisolone Acetate |
General description | Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti inflammatory and immunomodulating properties. |
Synonym | 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate; Omnipred; Pricortin; Prediacortine |
Purity | ≥98%(HPLC) | CAS Number | 52-21-1 |
Formula | C23H30O6 | Molecular Weight | 402.487 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti inflammatory and immunomodulating properties. As a glucocorticoid receptor agonist, prednisolone acetate binds to specific intracellular glucocorticoid receptors, and causes the ligand-receptor complex to be translocated to the nucleus where it initiates the transcription of glucocorticoid responsive genes such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
Application | Anti-Inflammatory Agents |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
