Product Name

Minocycline hydrochloride

General description

Minocycline Hydrochloride is a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities.

Synonym

(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide; hydrochloride

Purity

≥98%(HPLC)

CAS Number

13614-98-7

Formula

C²³H²⁷N³O⁷ · HCl

Molecular Weight

493.94

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Light yellow solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Minocycline Hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.

Application

Anti-Bacterial Agents

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov