Product Name

Hydralazine hydrochloride

General description

Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities.

Synonym

1-Hydrazinophthalazine hydrochloride

Purity

≥98%(HPLC)

CAS Number

304-20-1

Formula

C⁸H⁸N⁴  · HCl

Molecular Weight

196.64

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥30mg/mL

l  Biological Information

Biochem/Physiol   Actions

Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.

Application

1. Antihypertensive Agents

2. Vasodilator Agents

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov