l General Information |
Product Name | Tolfenamic acid |
General description | Tolfenamic acid is a COX inhibitor and prevents formation of prostaglandins. |
Synonym | 2-([3-Chloro-2-methylphenyl]amino)benzoic acid |
Purity | ≥98%(HPLC) | CAS Number | 13710-19-5 |
Formula | C14H12ClNO2 | Molecular Weight | 261.7 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥45mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Studies have shown that tolfenamic acid presents a non-dose dependent partial inhibition of irritant induced temperature rise as well as a dose-dependent inhibition of skin edema. By studying its NSAID properties more closely, it was noted a dose-related inhibition of serum thromboxane which indicated the inhibition of COX-1. In the same line, there was noted a inhibition of prostaglandin E2 synthesis which marks a related COX-2 inhibition. The maximal inhibition of thromboxane was greater than 80% as well as is proven to be a potent prostaglandin E inhibitor. |
Application | 1. Serotonin Antagonists 2. Prostaglandin Antagonists 3. Analgesics 4. Anti-Inflammatory Agents, Non-Steroidal 5. Calcium Channel Blockers |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
