l General Information |
Product Name | Stavudine |
General description | Stavudine is a nucleoside reverse transcriptase inhibitor analog of thymidine. |
Synonym | 1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine; BMY-27857;Sanilvudine; NSC 163661 |
Purity | ≥98%(HPLC) | CAS Number | 3056-17-5 |
Formula | C10H12N2O4 | Molecular Weight | 224.21 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥40mg/mL |
Ethanol | ≥10mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester age essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Stavudine is a nucleoside reverse transcriptase inhibitor analog of thymidine. Stavudine has been recommended to undergo phase-out management due to its long-term, irreversible side-effects. |
Application | 1. Anti-HIV Agents 2. Antimetabolites 3. Reverse Transcriptase Inhibitors |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
