l General Information |
Product Name | Enalapril Maleate |
General description | Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension and heart failure. |
Synonym | (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt; Renitec; Glioten; Vasotec; Baripril |
Purity | ≥98%(HPLC) | CAS Number | 76095-16-4 |
Formula | C20H28N2O5 · C4H4O4 | Molecular Weight | 492.52 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ~4mg/mL |
Water | Sparingly soluble |
l Biological Information |
Biochem/Physiol Actions | Enalapril Maleate is the maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
Application | 1. Angiotensin-Converting Enzyme Inhibitors 2. Antihypertensive Agents |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
