Phone:| Tech Support:| E-mail:
Home > Products > Small molecule > JAK/STAT > Niclosamide

Niclosamide

Product #: TL0363
Image SKU-Pack Size Stock Price($) Quantity

Documents

Details

l  General Information

Product Name

Niclosamide

General description

Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity.

Synonym

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Purity

≥98%(HPLC)

CAS Number

50-65-7

Formula

C13H8Cl2N2O

Molecular Weight

327.12

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow solid

Solubility(25℃)

DMSO

Insoluble

DMF

~12mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism.

Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents of STAT3 target genes. Altogether, this may inhibit growth of AR V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.

Application

1. Anticestodal Agents

2. Antinematodal Agents

3. Molluscacides

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


天问科技