Product Name

Chloroquine diphosphate

General description

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.

Synonym

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine; phosphoric acid; Chloroquine phosphate; Aralen phosphate; Chingamin phosphate; Chloroquine bis(phosphate)

Purity

≥98%(HPLC)

CAS Number

50-63-5

Formula

C¹⁸H²⁶ClN³  · 2H³PO⁴

Molecular Weight

515.86

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

Application

1. Anti-Inflammatory Agents, Non-Steroidal

2. Antimalarials

3. Filaricides

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov