l General Information |
Product Name | Mebendazole |
General description | Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent that acts by interfering with Carbohydrate metabolism and inhibiting polymerization of Microtubules. |
Synonym | methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate; Vermox; Telmin; Mebenvet; Pantelmin |
Purity | ≥98%(HPLC) | CAS Number | 31431-39-7 |
Formula | C16H13N3O3 | Molecular Weight | 295.298 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or yellow white solid |
Solubility(25℃) | DMSO | ~5mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Mebendazole is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Mebendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules. Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. |
Application | 1. Antinematodal Agents 2. Tubulin Modulators |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
