l General Information |
Product Name | Amlodipine besilate |
General description | Amlodipine Besylate is a long-acting dihydropyridine calcium channel blocker. |
Synonym | benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl 1,4-dihydropyridine-3,5-dicarboxylate; Amlodipine benzenesulfonate |
Purity | ≥98%(HPLC) | CAS Number | 111470-99-6 |
Formula | C26H31ClN2O8S | Molecular Weight | 567.05 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥10mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Amlodipine Besylate is the besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump. |
Application | 1. Antihypertensive Agents 2. Calcium Channel Blockers 3. Vasodilator Agents |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
