l General Information |
Product Name | Retigabine |
General description | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. |
Synonym | ethyl 4-(4-fluorobenzylamino)-2-aminophenylcarbamate; Ezogabine; D-23129; Trobalt |
Purity | ≥98%(HPLC) | CAS Number | 150812-12-7 |
Formula | C16H18FN3O2 | Molecular Weight | 303.337 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥30mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | As compared to other antiepileptic agents, ezogabine is unique in that it selectively activates potassium ion channels Kv 7.2-Kv7.5 and not cardiac Kv 7.1, thereby avoiding cardiac side effects. The antiepileptics, as a drug class, are routinely used in the treatment of a number of disease states in addition to epilepsy. Ezogabine is highly efficacious in a broad-spectrum of in vivo epilepsy and seizure models. A comparison of antiepileptic form activity of ezogabine with that of conventional anticonvulsants in in vitro models suggests that retigabine is especially likely to be useful in the treatment of pharmacoresistant epilepsy. Retigabine clearly attenuates pain-like behaviors in various animal models of neuropathic pain; it may also prove to be useful in treatment of clinical anxiety disorders. Clinical data obtained thus far indicate that retigabine is well tolerated in humans when titrated up to its therapeutic dose range. No tolerance, drug dependence, or withdrawal liability has been reported. Thus, retigabine may prove to be useful in the treatment of a diverse range of disease states in which neuronal hyperexcitability is a common underlying factor. |
Application | 1. Anticonvulsants 2. Membrane Transport Modulators |
l Packaging & Storage |
Packaging | 10mg; 50mg; 250mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
