Product Name

Gemcitabine hydrochloride

General description

Gemcitabine Hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity.

Synonym

4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2 one; hydrochloride; Gemzar; Gemcitabine HCl; LY188011 hydrochloride

Purity

≥99%(HPLC)

CAS Number

122111-03-9

Formula

C⁹H¹²ClF²N³O⁴

Molecular Weight

299.659

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥15mg/mL

l  Biological Information

Biochem/Physiol   Actions

Gemcitabine Hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

Application

1. Antiviral Agents

2. Enzyme Inhibitors

3. Antimetabolites, Antineoplastic

4. Immunosuppressive Agents

5. Radiation-Sensitizing Agents

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov