l General Information |
Product Name | Rifampicin |
General description | Rifampin, a semisynthetic derivative of rifamycin, is a DNA-dependent RNA polymerase inhibitor with broad antibacterial activity. |
Synonym | 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifamycin AMP |
Purity | ≥98%(HPLC) | CAS Number | 13292-46-1 |
Formula | C43H58N4O12 | Molecular Weight | 822.94 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Reddish-brown or brownish-red solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency. Rifampin is a semisynthetic derivative of rifamycin with broad antibacterial activity. Rifampin inhibits DNA-dependent RNA polymerase in susceptible bacteria and is often used in combination with other antibiotics for various infections including tuberculosis. |
Application | 1. Cytochrome P-450 CYP2B6 Inducers 2. Cytochrome P-450 CYP2C19 Inducers 3. Nucleic Acid Synthesis Inhibitors 4. Antibiotics, Antitubercular 5. Cytochrome P-450 CYP2C8 Inducers 6. Cytochrome P-450 CYP2C9 Inducers 7. Cytochrome P-450 CYP3A Inducers 8. Leprostatic Agents |
l Packaging & Storage |
Packaging | 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
