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Home > Products > Small molecule > Proteases > Carfilzomib

Carfilzomib

Product #: TL0274
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l  General Information

Product Name

Carfilzomib

General description

Carfilzomib, an epoxomicin derivate with potential antineoplastic activity, is a Proteasome Inhibitor.

Synonym

(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo 3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4 phenylbutanoyl]amino]pentanamide; PR-171

Purity

≥98%(HPLC)

CAS Number

868540-17-4

Formula

C40H57N5O7

Molecular Weight

719.924

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥40mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Carfilzomib is an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated   proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

l  Packaging & Storage

Packaging

10mg; 25mg; 100mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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