l General Information |
Product Name | Epirubicin hydrochloride |
General description | Epirubicin hydrochloride, an anthracycline which is the 4'-epi-isomer of doxorubicin, exerts its antitumor effects by interference with the synthesis and function of DNA. |
Synonym | (7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride; Ellence; Pharmorubicin; Farmorubicin; |
Purity | ≥98%(HPLC) | CAS Number | 56390-09-1 |
Formula | C27H30ClNO11 | Molecular Weight | 579.983 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Orange-red solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Epirubicin Hydrochloride is the hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. |
Application | 1. Antibiotics, Antineoplastic 2. Topoisomerase II Inhibitors |
l Packaging & Storage |
Packaging | 10mg; 50mg; 250mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
