Product Name

Sacubitril/valsartan (LCZ696)

General description

LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) .

Synonym

Sacubitril mixture with valsartan; Sacubitril/Valsartan

Purity

≥98%(HPLC)

CAS Number

936623-90-4

Formula

C²⁴H²⁹N⁵O³Na²·C²⁴H²⁹NO⁵Na·2.5H²O

Molecular Weight

915.98

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥20mg/mL

Ethanol

~6mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov