Product Name

Y27632(hydrochloride)

General description

Y27632 dihydrochloride is a selective ROCK1 (p160ROCK) inhibitor.

Synonym

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride; Y-27632 dihydrochloride; Y 27632 dihydrochloride

Purity

≥98%(HPLC)

CAS Number

129830-38-2

Formula

C¹⁴H²³Cl²N³O

Molecular Weight

320.258

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥40mg/mL

Ethanol

Insoluble

Water

≥10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

Application

1. Muscle Relaxants, Central

2. Antihypertensive Agents

3. Enzyme Inhibitors

l  Packaging & Storage

Packaging

5mg; 25mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov