Product Name

Procarbazine hydrochloride

General description

Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with   antineoplastic and mutagenic activities.

Synonym

4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide; hydrochloride; Matulane; Natunalar

Purity

≥99%(HPLC)

CAS Number

366-70-1

Formula

C¹²H²⁰ClN³O

Molecular Weight

257.762

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to light yellowish-white

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

Application

Antineoplastic Agents

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov