l General Information |
Product Name | Quinine |
General description | Quinidine is an alkaloid extracted from the bark of the Cinchona tree with antiarrhythmic and antimalarial effects. |
Synonym | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; Qualaquin |
Purity | ≥99%(HPLC) | CAS Number | 130-95-0 |
Formula | C20H24N2O2 | Molecular Weight | 324.424 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White solid |
l Biological Information |
Biochem/Physiol Actions | Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also hasgametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine. |
Application | 1. Muscle Relaxants, Central 2. Analgesics, Non-Narcotic 3. Antimalarials |
l Packaging & Storage |
Packaging | 5g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
