l General Information |
Product Name | UbeniMex |
General description | Ubenimex, a microbial metabolite and dipeptide, is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. |
Synonym | (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid; Bestatin; Ubenimexum |
Purity | ≥98%(HPLC) | CAS Number | 58970-76-6 |
Formula | C16H24N2O4 | Molecular Weight | 308.378 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ~0.5mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage and bone marrow stem cell as well as stimulates release of interleukin-1 and -2, thus further enhances its antitumor activity. |
Application | 1. Adjuvants, Immunologic 2. Anti-HIV Agents 3. Protease Inhibitors 4. Anti-Bacterial Agents 5. Immunologic Factors 6. Antibiotics, Antineoplastic |
l Packaging & Storage |
Packaging | 25mg; 100mg; 500mg |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
