l General Information |
Product Name | NSC-87877(sodium salt) |
General description | NSC-87877(sodium salt) is a cell-permeable inhibitor. |
Synonym | disodium;(7E)-8-oxo-7-[(6-sulfonatonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonate. |
Purity | ≥98%(HPLC) | CAS Number | 56932-43-5 |
Formula | C19H11N3Na2O7S2 | Molecular Weight | 503.411 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Black or dark brown solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells. |
l Packaging & Storage |
Packaging | 25mg; 100mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
