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AZD3759

Product #: TL0241
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Details

l  General Information

Product Name

AZD3759

General description

AZD3759 is a potent, oral active, CNS-penetrant EGFR inhibitor.

Synonym

[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate; AZD 3759; AZD-3759

Purity

≥98%(HPLC)

CAS Number

1626387-80-1

Formula

C22H23ClFN5O3

Molecular Weight

459.906

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥10mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

AZD3759 is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively.

l  Packaging & Storage

Packaging

10mg; 50mg

Storage temp.

-20

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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