l General Information |
Product Name | Vincristine sulfate |
General description | Vincristine Sulfate is the sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus with antimitotic and antineoplastic activities. |
Synonym | 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR |
Purity | ≥98%(HPLC) | CAS Number | 2068-78-2 |
Formula | C46H56N4O10 · H2SO4 | Molecular Weight | 923.04 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol Actions | Vincristine Sulfate is the sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
Application | 1. Antineoplastic Agents, Phytogenic 2. Tubulin Modulators |
l Packaging & Storage |
Packaging | 10mg; 50mg; 250mg |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
