l General Information |
Product Name | Tetrandrine |
General description | Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a non-selective calcium channel blocker. |
Synonym | (1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman; (+)-Tetrandrine; Tetrandrin; Fanchinine; D-Tetrandrine |
Purity | ≥98%(HPLC) | CAS Number | 518-34-3 |
Formula | C38H42N2O6 | Molecular Weight | 622.75 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ~1mg/mL |
Ethanol | ~2mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Tetrandrine is a natural,bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. |
Application | 1. Antiviral Agents 2. Calcium Channel Blockers 3. Immunosuppressive Agents 4. Antimalarials 5. Antineoplastic Agents, Phytogenic |
l Packaging & Storage |
Packaging | 5mg; 25mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
