Product Name

Proflavine Hemisulfate Hydrate

General description

Proflavine Hemisulfate, an acridine-derived fluorescent contrast and disinfectant agent, exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth.

Synonym

3,6-Diaminoacridine hemisulfate salt; Proflavin hemisulfate

Purity

≥98%(HPLC)

CAS Number

1811-28-5

Formula

C¹³H¹¹N³ · 0.5 H²SO⁴

Molecular Weight

258.29

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Dark red solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥20mg/mL

l  Biological Information

Biochem/Physiol   Actions

Proflavine is an acriflavine derivative which is a disinfectant bacteriostatic against many gram positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds.

Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth.

Application

Anti-Infective Agents, Local

l  Packaging & Storage

Packaging

1g

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov