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Docetaxel trihydrate

Product #: TL0197
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l  General Information

Product Name

Docetaxel trihydrate

General description

Docetaxel, a semi-synthetic, second-generation taxane, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules, displays potent and broad antineoplastic properties.

Synonym

RP56976 (NSC 628503) Trihydrate

Purity

≥99%(HPLC)

CAS Number

148408-66-6

Formula

C43H53NO14  · 3H2O

Molecular Weight

861.93

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.

Application

1. Antineoplastic Agents

2. Tubulin Modulators

l  Packaging & Storage

Packaging

10mg; 50mg; 250mg

Storage temp.

-20

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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