l General Information |
Product Name | Docetaxel trihydrate |
General description | Docetaxel, a semi-synthetic, second-generation taxane, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules, displays potent and broad antineoplastic properties. |
Synonym | RP56976 (NSC 628503) Trihydrate |
Purity | ≥99%(HPLC) | CAS Number | 148408-66-6 |
Formula | C43H53NO14 · 3H2O | Molecular Weight | 861.93 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥50mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. |
Application | 1. Antineoplastic Agents 2. Tubulin Modulators |
l Packaging & Storage |
Packaging | 10mg; 50mg; 250mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
