l General Information |
Product Name | Adapalene |
General description | Adapalene is a dual RAR and RXR agonist, used in the treatment of acne. |
Synonym | 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid; CD-271, Differin |
Purity | ≥98%(HPLC) | CAS Number | 106685-40-9 |
Formula | C28H28O3 | Molecular Weight | 412.52 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ~6mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Adapalene is a topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene . This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. |
Application | 1. Anti-Inflammatory Agents, Non-Steroidal 2. Dermatologic Agents |
l Packaging & Storage |
Packaging | 50mg; 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
