Product Name

Obeticholic Acid

General description

Obeticholic acid is a synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR).

Synonym

(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; INT-747; 6-ECDCA

Purity

≥98%(HPLC)

CAS Number

459789-99-2

Formula

C²⁶H⁴⁴O⁴

Molecular Weight

420.634

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Obeticholic acid (OCA) is a synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR) that is used to treat liver diseases including primary biliary cholangitis. Obeticholic acid has not been ed to elevations in serum enzyme levels during therapy, but has been ed to an increased rate of severe liver related adverse events such as ascites, jaundice and liver failure.

Application

l  Packaging & Storage

Packaging

50mg; 250mg

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov