l General Information |
Product Name | Quetiapine |
General description | Quetiapine is a dibenzothiazepine derivative with antipsychotic property. |
Synonym | 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; Seroquel |
Purity | ≥95%(HPLC) | CAS Number | 111974-69-7 |
Formula | C21H25N3O2S | Molecular Weight | 383.51 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Brown or dark brown sticky |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | N/A |
Water | N/A |
l Biological Information |
Biochem/Physiol Actions | Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. |
Application | Antipsychotic Agents |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
