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Belinostat

Product #: TL0170
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Details

l  General Information

Product Name

Belinostat

General description

Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

Synonym

N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; PXD-101; NSC726630;PX-105684

Purity

≥98%(HPLC)

CAS Number

414864-00-9

Formula

C15H14N2O4S

Molecular Weight

318.347

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Light pink solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.

Application

1. Antineoplastic Agents

2. Histone Deacetylase Inhibitors

l  Packaging & Storage

Packaging

10mg; 50mg; 250mg

Storage temp.

-20

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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