Product Name

Bleomycin sulfate

General description

Bleomycin Sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus.

Assay

1500-2000 IU/mg(Dried Basis)

CAS Number

9041-93-4

Formula

C55H85N17O25S4

Molecular Weight

1512.619

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or yellowish-white

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

~2mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Bleomycin Sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

Application

Antibiotics, Antineoplastic

l  Packaging & Storage

Packaging

5mg; 25mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov