Product Name

Tretinoin

General description

Tretinoin, a naturally-occurring acid of retinol, is an important regulator of gene during growth and development, and in neoplasms.

Synonym

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid; Retinoic acid; Tretinoin; Vitamin A acid; All-trans-Retinoic acid; Trans-Retinoic acid

Purity

≥98%(HPLC)

CAS Number

302-79-4

Formula

C²⁰H²⁸O²

Molecular Weight

300.442

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow to pale orange solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

~5mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic   leukemia (APL).

Tretinoin is a naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of   tretinoin has teratogenic and embryotoxic properties.

Application

1. Antineoplastic Agents

2. Keratolytic Agents

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov