Product Name

Mitoxantrone hydrochloride

General description

Mitoxantrone is a type II topoisomerase inhibitor with antineoplastic activity.

Synonym

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione; dihydrochloride;   Mitoxantrone dihydrochloride; Mitoxantrone HCl; Novantrone; Novantron

Purity

≥97%(HPLC)

CAS Number

70476-82-3

Formula

C²²H³⁰Cl²N⁴O⁶

Molecular Weight

517.404

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Dark blue solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with   antineoplastic activity. Mitoxantrone intercalates into and crosss DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

Application

1. Antineoplastic Agents

2. Topoisomerase II Inhibitors

3. Analgesics

l  Packaging & Storage

Packaging

50mg; 250mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov