l General Information |
Product Name | Apatinib |
General description | Apatinib is an orally bioavailable, selective VEGFR2 inhibitor. |
Synonym | N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide; YN968D1; AK162147 |
Purity | ≥98%(HPLC) | CAS Number | 811803-05-1 |
Formula | C24H23N5O | Molecular Weight | 397.482 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥20mg/mL |
Ethanol | N/A |
Water | N/A |
l Biological Information |
Biochem/Physiol Actions | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. |
Application | 1. Antineoplastic Agents 2. Protein Kinase Inhibitors |
l Packaging & Storage |
Packaging | 5mg; 25mg; 100mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
