Product Name

Carboplatin

General description

Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties.

Synonym

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum; Carboplatinum; Paraplatin; Cbdca;JM-8; CBDCA; NSC 241240

Purity

≥99%(HPLC)

CAS Number

41575-94-4

Formula

[C⁴H⁶(CO²)²]Pt(NH³)²

Molecular Weight

371.25

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

~10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-s, as well as DNA-protein cross-s. These carboplatin induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic.

Application

1. Antineoplastic Agents

2. Cross-ing Reagents

l  Packaging & Storage

Packaging

25mg; 100mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov