l General Information |
Product Name | Pemetrexed |
General description | Pemetrexed is a synthetic pyrimidine-based antifolate. |
Synonym | (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; Alimta |
Purity | ≥98%(HPLC) | CAS Number | 137281-23-3 |
Formula | C20H21N5O6 | Molecular Weight | 427.417 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off-white solid |
l Biological Information |
Biochem/Physiol Actions | Preclinical studies have shown that pemetrexed inhibits the in vitro growth of mesothelioma cell lines (MSTO-211H, NCI-H2052). Studies with the MSTO-211H mesothelioma cell line showed synergistic effects when pemetrexed was combined concurrently with cisplatin. Pemetrexed is a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
Application | 1. Enzyme Inhibitors 2. Antineoplastic Agents 3. Folic Acid Antagonists 4. Nucleic Acid Synthesis Inhibitors |
l Packaging & Storage |
Packaging | 50mg; 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
