Product Name

Cyclophosphamide monohydrate

General description

Cyclophosphamide is the precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide.

Synonym

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; hydrate; Cyclophosphamide hydrate; Endoxan monohydrate; Cytoxan

Purity

≥99%(HPLC)

CAS   Number

6055-19-2

Formula

C⁷H¹⁵Cl²N²O²P · H²O

Molecular   Weight

279.098

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥10mg/mL

Water

≥10mg/mL

l  Biological Information

Biochem/Physiol   Actions

Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. Cyclophosphamide therapy is associated with minor transient serum enzyme elevations and has been ed to rare cases of acute liver injury. In addition, when given in high doses as a part of a myeloablative therapy, cyclophosphamide can cause acute sinusoidal obstruction syndrome.

Application

1. Antineoplastic Agents, Alkylating

2. Immunosuppressive Agents

3. Antirheumatic Agents

4. Myeloablative Agonists

5. Mutagens

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov