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Sunitinib

Product #: TL0084
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Details

l  General Information

Product Name

Sunitinib

General description

Sunitinib is an indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity.

Synonym

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; SU-11248; Sutent;

Purity

≥99%(HPLC)

CAS Number

557795-19-4

Formula

C22H27FN4O2

Molecular Weight

398.482

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Orange or yellow solid

Solubility(25℃)

DMSO

≥20mg/mL

Ethanol

Very slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Sunitinib is the orally bioavailable an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.

Application

1.Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

2.Substances that inhibit or prevent the proliferation of neoplasms.

l  Packaging & Storage

Packaging

50mg; 250mg; 1g;

Storage temp.

0-5

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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