l General Information |
Product Name | Nicardipine |
General description | Nicardipine is a potent calcium channel blockader with marked vasodilator action. |
Synonym | 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nicardipinum; Nicardipino; Cardene |
Purity | ≥99%(HPLC) | CAS Number | 55985-32-5 |
Formula | C26H29N3O6 | Molecular Weight | 479.533 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Pale yellow to yellow solid |
l Biological Information |
Biochem/Physiol Actions | Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. |
Application | 1. Antihypertensive Agents Drugs used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. 2. Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. 3. Vasodilator Agents Drugs used to cause dilation of the blood vessels. |
l Packaging & Storage |
Packaging | 250mg; 1g; |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
