Product Name

多韦替尼乳酸盐(Dovitinib lactate)

General description

Dovitinib Lactate is lactate salt of Dovitinib with potential antineoplastic activity.

Synonym

(3E)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic acid; hydrate; TKI258; Dovitinib lactate monohydrate;

Purity

≥98%(HPLC)

CAS Number

915769-50-5

Formula

C²⁴H²⁹FN⁶O⁵

Molecular Weight

500.531

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Light yellow green or green solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

~1mg/mL

Water

≥25mg/mL

l  Biological Information

Biochem/Physiol   Actions

Dovitinib Lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional   reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

l  Packaging & Storage

Packaging

5mg; 100mg

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov