l General Information |
Product Name | Dasatinib monohydrate |
General description | Dasatinib monohydrate is a selective tyrosine kinase receptor inhibitor. |
Synonym | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;hydrate; Dasatinib hydrate; BMS 35482503; Dasatinib.H2O |
Purity | ≥99%(HPLC) | CAS Number | 863127-77-9 |
Formula | C22H28ClN7O3S | Molecular Weight | 506.022 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to pale yellow solid |
Solubility(25℃) | DMSO | ≥15mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or of the endogenous protein and by way of virally-encoded kinase genes |
Application | 1. Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. 2. Protein Kinase Inhibitors Agents that inhibit PROTEIN KINASES. |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
