Product Name

(±)-Baclofen

General description

Baclofen is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B   RECEPTORS.

Synonym

(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; Lioresal;

Purity

≥99%(HPLC)

CAS Number

1134-47-0

Formula

C¹⁰H¹²ClNO²

Molecular Weight

213.66

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Sparingly soluble

Ethanol

Insoluble

Water

Slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission.

Application

1.      GABA-B Receptor Agonists

Endogenous compounds and drugs that bind to and activate GABA-B RECEPTORS.

2.      Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle   spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS.

l  Packaging & Storage

Packaging

1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov