Product Name

Procaine HCl

General description

Procaine HCl is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties.

Synonym

4-Aminobenzoic acid 2-diethylaminoethyl ester hydrochloride; Novocaine hydrochloride;

Purity

≥99%(HPLC)

CAS   Number

51-05-8

Formula

H²NC⁶H⁴CO²CH²CH²N(C²H⁵)2·HCl

Molecular   Weight

272.77

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol   Actions

Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Application

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the   tendency of voltage-dependent sodium channels to activate.

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov