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Sildenafil citrate

Product #: TL0045
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Details

l  General Information

Product Name

Sildenafil citrate

General description

Sildenafil citrate functions as a selective and competitive inhibitor of type 5 phosphodiesterases (PDE5) on smooth muscle cells in the penis and pulmonary vasculature.

Synonym

1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt; Revatio; UK-92,480;

Purity

≥98%(HPLC)

CAS   Number

171599-83-0

Formula

C22H30N6O4S ·C6H8O7

Molecular   Weight

666.70

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥10mg/mL

Ethanol

Insoluble

Water

Slightly soluble

l  Biological Information

Biochem/Physiol   Actions

Sildenafil Citrate is the citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase, resulting in vasodilation in the corpus cavernosum of the penis and penile erection.

Application

1.      Urological Agents

Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION.

2.      Vasodilator Agents

Drugs used to cause dilation of the blood vessels.

3.      Phosphodiesterase 5 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 5.

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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