l General Information |
Product Name | Sildenafil citrate |
General description | Sildenafil citrate functions as a selective and competitive inhibitor of type 5 phosphodiesterases (PDE5) on smooth muscle cells in the penis and pulmonary vasculature. |
Synonym | 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt; Revatio; UK-92,480; |
Purity | ≥98%(HPLC) | CAS Number | 171599-83-0 |
Formula | C22H30N6O4S ·C6H8O7 | Molecular Weight | 666.70 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Off-white solid |
Solubility(25℃) | DMSO | ≥10mg/mL |
Ethanol | Insoluble |
Water | Slightly soluble |
l Biological Information |
Biochem/Physiol Actions | Sildenafil Citrate is the citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase, resulting in vasodilation in the corpus cavernosum of the penis and penile erection. |
Application | 1. Urological Agents Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. 2. Vasodilator Agents Drugs used to cause dilation of the blood vessels. 3. Phosphodiesterase 5 Inhibitors Compounds that specifically inhibit PHOSPHODIESTERASE 5. |
l Packaging & Storage |
Packaging | 250mg; 1g |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
