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Lomefloxacin HCl

Product #: TL0044
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Details

l  General Information

Product Name

Lomefloxacin HCl

General description

Lomefloxacin HCl is the hydrochloride salt of Lomefloxacin. Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.

Synonym

1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Purity

≥98%(HPLC)

CAS   Number

98079-52-8

Formula

C17H19F2N3O3 · HCl

Molecular   Weight

387.81

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

~1mg/mL

Ethanol

insoluble

Water

~5mg/mL

l  Biological Information

Biochem/Physiol   Actions

Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis.

Application

1.      Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA.

2.      Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

l  Packaging & Storage

Packaging

50mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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