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Letrozole

Product #: TL0025
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Details

l  General Information

Product Name

Letrozole

General description

Letrozole is an Aromatase Inhibitor.

Synonym

4,4-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

Purity

≥98%(HPLC)

CAS   Number

112809-51-5

Formula

C17H11N5

Molecular   Weight

285.30

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

insoluble

Water

insoluble

l  Biological Information

Biochem/Physiol   Actions

Letrozole is an aromatase inhibitor used in the treatment of breast cancer. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. As breast tissue is stimulated by estrogens, decreasing their production is a way of suppressing recurrence of the breast tumor tissue.

Letrozole is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.

Application

1.      Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS.

2.      Aromatase Inhibitors

Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones

l  Packaging & Storage

Packaging

50mg; 250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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